구성원

구성원

배옥남

Chongsuk Ryou 류종석 교수

Research Keywords
연구키워드
  • #neurodegenerative disease #pathogenesis #therapeutics #diagnosis #Alzheimer’s disease #prion disease #protein misfolding #animal model #cell-based model #test tube assay
  • #퇴행성뇌질환 #발병기전 #치료제 #진단 #알츠하이머병 #프리온병 #단백질오접힘 #동물모델 #세포모델 #시험관시험법
Research Objectives
연구목표
  • To understand pathogenesis of neurodegenerative disorders (prion disease, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis) caused by protein misfolding and aggregation
  • To establish suppressants, therapeutics, and diagnostics based on molecular pathogenesis neurodegenerative protein misfolding disorders
  • To establish disease models for neurodegenerative protein misfolding disorders
  • To establish drug efficacy test using these models
  • 단백질 오접힘에 의해 발생하는 퇴행성 뇌질환 (프리온병, 알츠하이머병, 파킨슨병, 루게릭병 등) 발병기전 이해
  • 퇴행성 뇌질환의 발병기전 기반 억제, 치료, 진단 방법 확립
  • 퇴행성 뇌질환 연구를 위한 전주기 모델 확립
  • 퇴행성 뇌질환 모델을 이용한 약효평가법 확립
Brief Research Experience
주요경력
  • Professor, Department of Pharmacy, College of Pharmacy, Hanyang University
  • Assistant Professor, Department of Microbiology, Immunology and Molecular Biology, University of Kentucky College of Medicine
  • Assistant Professor, Department of Neurology, University of California San Francisco School of Medicine
  • Postdoc, Institute for Neurodegenerative diseases, University of California San Francisco School of Medicine (French Alzheimer's Foundation Fellowship)
  • > 50 articles (SCIE), 6 books and book chapters
  • 9 patents (Korean, US), 2 tech transfer (Korea, Canada), Company establishment (Proteios Biotech, Inc.)
  • Research funded from Korea National Research Foundation, Ministry of Education, Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention, US National Institutes of Health
  • Review editor, Frontiers in Molecular Neuroscience; Editor, Journal of Microbiology and Biotechnology
  • 한양대학교 약학대학 약학과 교수
  • 미국 University of Kentucky 의과대학 미생물학면역학분자생물학과 교수
  • 미국 University of California San Francisco 의과대학 신경과 교수
  • 미국 University of California San Francisco 퇴행성뇌질환연구소, 박사후연구원 (French Alzheimer's Foundation 펠로우쉽 수혜)
  • 논문 (SCIE) > 50편 게재, 저서 (book, book chapter, 교과서) 6권
  • 특허 국내 8건, 국제 1건, 기술이전 국내 1건, 국제 1건
  • 교원실험실창업 ㈜ 프로테이오스바이오텍
  • 연구재단, 교육부, 보건복지부, 질병관리청 국가연구과제, 미국 NIH 과제 수행
  • 학술저널 Frontiers in Molecular Neuroscience 편집위원, Journal of Microbiology and Biotechnology 편집인
Research Areas
연구분야
  • Protein conformational conversion by misfolding
  • Mechanism of propagation of misfolded protein aggregates
  • Control of formation and propagation of misfolded protein aggregates
  • Pathogenesis of neurodegenerative disorders (prion disease, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis) caused by protein misfolding and aggregation
  • 오접힘에 의한 단백질구조변환 연구
  • 단백질 응집체 증식 기전 연구
  • 단백질 응집체 형성/증식 억제 연구
  • 단백질 응집에 의한 퇴행성 뇌질환 (프리온병, 알츠하이머병, 파킨슨병, 루게릭병 등) 연구
Thesis
논문
  • Kim DH, Kim J, Lee H, Lee D, Im SM, Kim YE, Yoo M, Cheon YP, Bartz JC, Son YJ, Choi EK, KimYS, Jeon JH, Kim HS, Lee S,Ryou C*, Nam TG* (2023) Synthesis and anti-prion aggregation activityof acylthiosemicarbazide analogues. J Enzyme Inhib Med Chem. 38(1):2191164. * co-Correspondence
  • Park H*, Kim J,Ryou C*. (2023) A three-dimensional spheroid co-culture system of neurons andastrocytes derived from Alzheimer's disease patients for drug efficacy testing. Cell Prolif. 56:e13399. *co-correspondence
  • Lee S, Lee H, Kim J, Kim JH, Gao EM, Lee Y, Yoo M, Trinh THT, Kim J, Kim CY*,Ryou C*. (2022)The Effect ofCurcuma phaeocaulisValeton (Zingiberaceae) Extract on Prion Propagation in Cell-Based and Animal Models. Int J Mol Sci. 24(1):182. * co-correspondence
  • Lee JH, Park SH,Ryou C, Gye MC. (2022) Phthalate plasticizer decreases the prion-like proteindoppel essential for structural integrity and function of spermatozoa. Ecotoxicol Environ Saf.246:114159.
  • Mays CE, Trinh THT, Telling G, Kang HE,Ryou C. (2022) Endoproteolysis of cellular prion protein byplasmin hinders propagation of prions. Front Mol Neurosci. 15:990136./li>
Research Topics
연구내용
  • Protein conformational conversion by misfolding

    Structural conversion of prion protein and amyloid-beta conformer

  • Mechanism of propagation of misfolded protein aggregates

    Aggregation of prion protein and amyloid-beta conformer

    Propagation of prion protein and amyloid-beta aggregates

    Cofactors involved in aggregation and propagation of prion protein and amyloid-beta

  • Control of formation and propagation of misfolded protein aggregates

    Protein aggregate precursor-targeted disease modifier, therapeutics and diagnostics

    Protein aggregation-targeted disease modifier, therapeutics and diagnostics

    Pre-formed protein aggregate-targeted disease modifier, and therapeutics

    Cellular process-targeted disease modifier, and therapeutics

  • Pathogenesis of neurodegenerative disorders (prion disease, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis) caused by protein misfolding and aggregation

    Recombinant protein production of various aggregation-prone proteins and their mutants by protein engineering

    Test tube protein aggregation assay for various aggregation-prone proteins

    Cultured cell models for various neurodegenerative caused by protein misfolding and aggregation (including 3D spheroid culture)

    Animal models for various neurodegenerative caused by protein misfolding and aggregation (disease induced model, knock-out mice, transgenic mice, knock-in mice, etc)

    Behavior tests, drug efficacy tests, toxicity tests, histology/pathology, biochemical evaluation, molecular biological evaluation using animal models

    Transmissibility of neurodegenerative caused by protein misfolding and aggregation