구성원

구성원

조광현

Seyoung Koo 구세영 교수

  • DepartmentDepartmentProf. of Chemical and Molecular Engineering, College of Science and Convergence Technology / Associate Professor
  • E-mailE-mailsykoo@hanyang.ac.kr
  • Office PhoneOffice Phone031-400-5501
  • 학과/직책학과/직책과학기술융합대학 화학분자공학과 / 조교수
  • 이메일이메일sykoo@hanyang.ac.kr
  • 전화번호전화번호031-400-5501
Research Keywords
연구키워드
  • #Fluorescent chemical probe, #Phototherapeutic agent, #Prodrug, #RNA delivery platform, #Theranostic agent
  • #형광화학프로브, #광치료제, #약물전구체, #RNA 전달체, #진단치료제
Research Objectives
연구목표
생명현상의 관찰 및 조절을 위한 화학생물학 도구 개발
  • 생체 이미징용 형광화학프로브 개발
  • 질병세포 검출 및 진단시스템 개발
  • 질병 세포 표적형 약물전달시스템 개발
  • 생리활성 지질 기반 나노입자 개발

Development of chemical biology tools for the monitoring and modulation of biological phenomena

  • Development of fluorescent chemical probes for in vivo imaging
  • Development of diagnostic systems for the detection and identification of pathological cells
  • Development of targeted drug delivery systems
  • Development of bioactive lipid-based nanoparticles
Brief Research Experience
주요경력
  • 협성대학교 의생명화학과 조교수 (2023.03-2024.02)
  • 하버드의학전문대학원 브리검여성병원 방문연구원 (2022.03-2023.02)
  • 고려대학교 차세대분자테라노시스 연구단 연구교수 (2019.09-2023.02)
  • 수행과제: 한국연구재단, 세종과학펠로우십 (2022-2027), 박사후국내연수 (2020-2022)
  • Assistant Professor, Hyupsung University (2023.03-2024.02)
  • Visiting Research Scholar, Brigham and Women's Hospital, Harvard Medical School (2022.03-2023.02)
  • Research Professor, Next-generation Molecular Theranostics Lab., Korea University (2019.09-2023.02)
  • Research Grant: NRF, Sejong Science Fellowship (2022-2027), Post-Doctoral Domestic Training Fellowship (2020-2022)
Research Areas
연구분야
  • 생체분자 감응성 형광화학프로브
  • 다기능성 광촉매
  • 약물전구체/약물전달시스템
  • 암, 염증, 노화 관련 질병의 진단치료제 개발
  • Stimuli-responsive fluorescent chemical probes
  • Multifunctional phototherapeutic agent
  • Prodrug/drug delivery system
  • Development theranostic agent for cancer, inflammation, aging
Thesis
논문

1.   S. Koo,† E. J. Lee,† H. Xiong, D. H. Yun, M. M. McDonald, S. I. Park,* J. S. Kim* “Real-Time Live Imaging of Osteoclast Activation via Cathepsin K Activity in Bone Diseases” Angew. Chem. Int. Ed. 2024, 63, e202318459.

2. H. S. Jung,† S. Koo,† M. Won,† S. An, H. Park, J. L. Sessler,* J. Han,* J. S. Kim* “Cu(Ⅱ)-BODIPY photosensitizer for CAIX overexpressed cancer stem cell therapy” Chem. Sci. 2023, 14, 1808-1819.

3. S. Koo,† M.-G. Lee,† A. Sharma, M. Li, X. Zhang, K. Pu,* S.-G. Chi,* J. S. Kim* “Harnessing GLUT1 Targeted Pro-oxidant Ascorbate for Synergistic Phototherapeutics” Angew. Chem. Int. Ed. 2022, 61, e202110832.

4. S. Koo,† M. Won,† H. Li,† W. Y. Kim, M. Li, C. Yan, A. Sharma, Z. Guo,* W.-H. Zhu,* J. L. Sessler,* J. Y. Lee,* J. S. Kim* “Harnessing α-L-Fucosidase for In Vivo Cellular Senescence Imaging” Chem. Sci. 2021, 12, 10054-10062.

5. M. Won,† S. Koo,† H. Li,† J. L. Sessler,* J. Y. Lee,* A. Sharma,* J. S. Kim* “An Ethacrynic Acid-Brominated BODIPY Photosensitizer (EA-BPS) Construct Enhances the Lethality of Reactive Oxygen Species in Hypoxic Tumor-Targeted Photodynamic Therapy” Angew. Chem. Int. Ed., 2021, 60, 3196-3204.
Research Topics
연구내용

 

 

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