구성원

구성원

정혜영

Sun-Joon Min 민선준 교수

  • DepartmentDepartmentProf. Dept. of Chemical & Molecular Engineering, College of Science and Convergence Technology / Professor
  • E-mailE-mailsjmin@hanyang.ac.kr
  • Office PhoneOffice Phone031-400-5502
  • HomepageHomepagehttps://sites.google.com/site/sunjoonmin/
Research Keywords
연구키워드
  • #Chemical Library #Chemical Probes #Molecular Imaging #Bioconjugation #Organocatalysis #Heterocycles #Bioorthogonal Reaction #Small Molecules #Linker Chemistry #Theranostics
  • #화합물 라이브러리 #화학적 탐침자 #분자영상 #바이오콘쥬게이션 #유기촉매반응 #헤테로고리화합물 #생체직교반응 #저분자 화합물 #링커화학 #테라노스틱스
Research Objectives
연구목표
  • Development of Chemical Probes for Biomedical Applications
  • New Synthetic Methodologies for Functional Heterocyclic Biomolecules
  • Chemical Library Containing Various Chemical Spaces
  • Reactive Fluorescent Sensors for Detection of Biological Targets
  • Therapeutics for Treatment of Brains Disorders, Inflammations and Infections
  • Theranostics Platform Technology using Linker Chemistry
  • 의약학 및 화학생물학에 적용되는 화학적 탐침자(chemical probes) 개발
  • 생체 분자(biomolecules) 기능 제어 헤테로고리 화합물의 신규 유기 합성법을 개발
  • 다양한 구조의 화합물 라이브러리 (chemical library)를 구축
  • 생체 표적 검출을 위한 반응성 형광 화학적 센서 개발
  • 뇌질환, 항염증, 및 감염증 치료제 개발
  • 링커 화학을 이용한 테라노스틱스 플랫폼 기술 개발
Brief Research Experience
주요경력
  • Professor, Hanyang University ERICA Campus (2015-present)
  • Principal Investigator, Korea Institute of Science and Technology (2008~2015)
  • Adjunct Professor, University of Science and Technology (2008~2015)
  • Visiting Scholar, University of North Carolina, Chapel Hill (2012~2013)
  • Postdoctoral Research Scientist, Columbia University, (2005~2008)
  • Research Grant:

    National Research Foundation of Korea (Basic Research Laboratory)

    Gyeonggi province/Ansan city (Gyeonggi-do Regional Research Center)

    Korea Health Industry Development Institute

  • 교수, 한양대학교 화학분자공학과 (2015년~현재)
  • 책임/선임연구원, 한국과학기술연구원 (2008~2015년)
  • 겸임교수, 과학기술연합대학원 (2008~2015년)
  • 방문연구원, University of North Carolina, Chapel Hill (2012~2013년)
  • 박사후연구원, Columbia University, (2005~2008년)
  • 수행과제 지원 기관:

    한국연구재단 – 실리카 나노테라노스틱스 기초연구실 (BRL)

    경기도/안산시 – 액상유기수소운반체(LOHC) 기반 수소 저장 기술 연구 (GRRC)

    한국보건산업진흥원 – 비결핵 항산균 치료 후보물질 개발 연구

Research Areas
연구분야
  • New synthetic methodologies and target oriented synthesis
  • Development of small molecule-based therapeutic agents for various diseases
  • Chemical probes for detecting a specific biological target
  • Development of multi-modal silica nanotheranostics platform
  • 유기촉매를 이용한 신규 유기 합성법 개발 및 생리활성물질의 전합성 연구
  • 저분자 화합물 기반 약물 설계 및 치료제 개발
  • 생물학적 표적 검출을 위한 화학적 탐침자 개발
  • 다기능 실리카 나노테라노스틱스 플랫폼 기술 개발
Thesis
논문
  • 1. Kim, G. U., Cho, H., Lee, J. K., Lee, J. Y., Tae, J., Min, S.-J., Kang, T., Cho, Y. S. (2023) Stereoselective synthesis of 1,6-diazecanes by tandem aza-Prins type dimerization and cyclization process. Chem. Comm., 59:82-85.
  • 2. Jung, S., Yoon, S., Lee, J. K., Min, S.-J. (2022) Stereoselective Synthesis of Benzo[a]quinolizidines via Aerobic DDQ-Catalyzed Allylation and Reductive Cyclization. ACS Omega, 7:32562–32568.
  • 3.Lee, J., Kim, J., Heo, I., Kim, S. J., Jang, S., Lee, H.-Y., Jang, K.-S., Yang, C.-S., Lee, Y., Yoo, W. C., Min, S.-J. (2022) One-pot bifunctionalization of silica nanoparticles conjugated with bioorthogonal linkers: application in dual-modal imaging. Biomaterials Sci.,10:3540-3546.
  • 4.Lee, D., Lee, E., Kim, K., Cho, E., Mun, S.-J., Son, W., Jeon, H.-Y., Kim, H. K., Jeong, Y. J., Jang, S., Lee, Y., Oh, J. E., Yoo, H. H., Lee, Y., Min, S.-J., Yang, C.-S. (2022) Discovery of Mycobacterium tuberculosis Rv3364c-derived small molecules as potential therapeutic agents to target SNX9 for sepsis. J. Med. Chem., 65:386-408.
  • 5.Hwang, Y. J., Hyeon, S. J., Kim, Y., Lim, S., Lee, M. Y., Kim, J., Londhe, A. M., Gotina, L., Kim, Y., Pae, A. N., Cho, Y. S., Seong, J., Seo, H., Kim, Y. K., Choo, H., Ryu, H., Min, S.-J. (2021) Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington’s disease mouse model. J. Enz. Inhib. Med. Chem., 36:856-868.
  • 6. Kim, Y.-R., Kim, J.-S., Gu, S.-J., Jo, S., Kim, S., Kim, S. Y., Lee, D., Jang, K., Choo, H., Kim, T.-H., Jung, J. U., Min, S.-J., Yang, C.-S. (2020) Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis. Scientific Reports, 10:4570.
  • 7. Kim, J., Kim, Y., Abdelazem, A. Z., Kim, H. S., Kim, J. O., Park, Y.-J., Min, S.-J. (2020) Development of carbapenem-based fluorogenic probes for the clinical screening of carbapenemase-producing bacteria. Bioorg. Chem., 94:10405.
Research Topics
연구내용
  • Development of New Synthetic Methods Using Organocatalysts

    C-C Bond forming reactions via oxidative C-H activation (Mannich reactions)

    Development of azacyclic compounds library and total synthesis of natural products

    Visible light photoredox catalysis using quinones as organocatalyst

  • Development of small molecule based therapeutic drugs

    Synthesis of antioxidant small molecules targeting mitochondria

    Anti-inflammatory/antibacterial peptide-derived small molecules as antiseptic agents

    Identification of new drug candidates for treatment of nontuberculous mycobacteria (NTM)

  • Chemical probes for detecting a specific biological target

    Development of small molecules to regulate aggregated proteins associated with neurodegenerative diseases

    Beta-lactam based chemical sensors for detection of multidrug resistant bacteria

    Identification of 5-HT selective agonists and PET radiopharmaceuticals

    Synthesis of biotin-conjugated L-DNA monomer

  • Development of multi-modal silica nanotheranostics platform

    Covalent surface modification of silica nanoparticles using allylsilanes

    Bioorthogonal reactions based on tetrazine cycloaddition

    Development of multi functional PET/MRI nanomedicines

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