구성원

구성원

김원동

Dong Wook KIM 김동욱 교수

  • 학과/직책학과/직책약학대학 약학과 / 교수
  • 이메일이메일dongwook@hanyang.ac.kr
  • 전화번호전화번호031-400-5806
  • 홈페이지홈페이지pmm.hanyang.ac.kr
Research Keywords
연구키워드
  • #Collera #V. cholerae #toxin #vaccine #Shigella
  • #콜레라 #콜레라균 # 독소 # 백신 #세균성이질균
Research Objectives
연구목표
  • Comparative analysis of genome sequence and evolution of V. cholerae
  • Regulation of expression of cholera toxin and virulence genes in V. cholerae
  • Development of next-generation of cholera vaccines
  • 유전체 염기서열 분석을 통한 콜레라균의 진화 연구
  • 콜레라균의 독소와 독성 유전자 발현 조절에 대한 이해
  • 고효능 차세대 콜레라 백신 개발
Brief Research Experience
주요경력
  • Professor, College of Pharmacy, Hanyang Univ. (2011 – present)
  • Visiting Professor, Nihon University medical school, Tokyo Japan (2018)
  • Principal Investigator, International Vaccine Institute (2004 – 2011)
  • Editor, Journal of Microbiology and Biotechnology (2009 – 현재)
  • Publications, Nature (2011), PLoS Pathog. (2014), Trends Microbiol. (2015), PNAS (2017), Front. Microbiol. (2020).
  • 한양대학교 약학과 교수 (2011년 – 현재)
  • 방문교수, Nihon University medical school, Tokyo Japan (2018)
  • 국제백신연구소 (International Vaccine Institute) 책임연구원 (2004 – 2011)
  • 편집위원, Journal of Microbiology and Biotechnology (2009 – 현재)
  • 주요논문, Nature (2011), PLoS Pathog. (2014), Trends Microbiol. (2015), PNAS (2017), Front. Microbiol.(2020) 등
Research Areas
연구분야
  • Regulation of virulence gene expression in V. cholerae
  • Genome analysis and evolution of V. cholerae
  • Development of next-generation cholera vaccine
  • Development of molecular diagnostics of infectious diseases using LAMP technology
  • 콜레라균의 독소 발현 메커니즘
  • 콜레라균 유전체 염기서열 분석 및 진화 연구
  • 콜레라균 백신 개발
  • LAMP 기술을 활용한 감염질환 진단법 개발
Research Topics
연구내용
  • Changes in the global population of Vibrio cholerae

    The analysis of the whole-genome sequences of Vibrio cholerae strains from previous and current cholera pandemics has demonstrated that genomic changes and alterations in cholera toxin were major features in the evolution of V. cholerae.

    By understanding the mechanisms and driving forces of historical and current changes in the V. cholerae population, it would be possible to predict the direction of such changes and the evolution of new variants; this has implications for the battle against cholera.

  • Regulation of virulence gene expression in V. cholerae

    The expression of virulence genes, such as CT and TCP during V. cholerae infection is controlled by ToxT, which is regulated by ToxR/ToxS and TcpP/TcpH in the intestinal environment.

    Recently, we have reported that the toxT-139F allele facilitates the production of CTand TCP in V. cholerae strains., which implies that in vitro virulence gene expression in V. cholerae needs to be interpreted from another point of view.

    Moreover, we have found that V. cholerae strains could be manipulated to constitutively express the virulence genes.

    These results could be applied in studies of cholera toxin as effective mucosal adjuvant development and next-generation cholera vaccines.

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