구성원

구성원

김주연

Wondong Kim 김원동 교수

Research Keywords
연구키워드
  • #Metabolite profiling #Metabolic diseases #Translational research #Pathophysiology #Preclinical efficacy evaluation
  • #대사체분석 #대사질환 #중개연구 #병태생리 #전임상약효평가
Research Objectives
연구목표
  • Application of metabolomics to metabolic diseases: Disease-to-target discovery and preclinical study
  • 대사체 분석을 활용한 질환의 치료 타겟 발굴 및 전임상약리 연구
김원동1.jpg
Brief Research Experience
주요경력
  • Research Professional, Life Sciences, LG Chem
  • Research Fellow, Massachusetts General Hospital/Harvard Medical School
  • Researcher, Asan Institute for Life Sciences, Asan Medical Center
  • Published research articles: metabolic diseases

    Type 2 diabetes (Cell Metabolism 2019), Kidney diseases (Nature 2016; Journal of Clinical Investigation 2020), Psoriasis (Cells 2020), Obesity (Journal of Cachexia, Sarcopenia and Muscle 2021)

  • Funding: National Research Foundation of Korea
  • LG화학 생명과학사업본부, 신약연구센터
  • Massachusetts General Hospital/Harvard Medical School, Research Fellow
  • 서울아산병원 의생명연구소
  • 다양한 대사성 질환 연구 논문 출판

    제2형 당뇨 (Cell Metabolism 2019), 급성 및 만성 신장질환 (Nature 2016; Journal of Clinical Investigation 2020), 건선 (Cells 2020), 비만 (Journal of Cachexia, Sarcopenia and Muscle 2021)

  • 수행과제 지원 기관: 한국연구재단
Research Areas
연구분야
  • in vitro, in vivo (animal) model studies in metabolic diseases
  • Understanding pathological mechanisms of metabolic diseases using metabolite profiling
  • Translational research: collaboration with hospitals and pharmaceutical industry
  • Major research topics: metabolomics (lipidomics), NASH/fibrosis, immunometabolism/cancer metabolism
  • 다양한 질환의 in vitro, in vivo (animal) 모델 연구
  • 대사체 분석과 질환 모델을 활용한 대사성 질환의 병리기전 및 치료 타겟 발굴 연구 수행
  • 병원 및 산업체와의 공연연구를 통한 중개연구
  • 주연구분야: 대사체(지질) 분석, 비알콜성지방간염(NASH)-섬유화 질환, 면역대사 및 암대사 등
Thesis
논문
  • Kim JY, Kim HM, Kim JH, Guo S, Lee DH, Lim GM, Kim W*, Kim CY* (2023). Salvia plebeia R.Br. and Rosmarinic Acid Attenuate Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes. International journal of molecular sciences. 24, 1876. (*co-corresponding)
  • Kim A, Koo JH, Jin X, Kim W, Park SY, Park S, Rhee EP, Choi CS, Kim SG. (2021). Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes. Journal of Cachexia, Sarcopenia and Muscle. 12, 1669-1689.
  • Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP. (2020). Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. Journal of Clinical Investigation 130, 1513-1526.
  • Kim DH*, Kim WD*, Lee SJ and Moon DH. (2020). TGFb1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells. Cell Death & Disease 11, 406. (*co-first authors)
  • Gaire BP*, Lee CH*, Kim W*, Sapkota A, Lee DY and Choi JW. (2020). Lysophosphatidic acid receptor 5-mediated NLRP3 inflammasome activation in macrophages drives imiquimod-induced psoriasis. Cells 9, 1753. (*co-first authors)
  • Kim W, Deik A, Gonzalez C, Gonzalez ME, Fu F, Ferrari M, Churchhouse CL, Florez JC, Jacobs SBR, Clish CB and Rhee EP (2019). Polyunsaturated fatty acid desaturation is a mechanism for glycolytic NAD+ recycling. Cell Metabolism 29, 856-870.e7.
  • Jang HY, Kim DH, Lee HJ, Kim WD, Kim SY, Hwang JJ, Lee SJ and Moon DH. (2019). Schedule-dependent synergistic effects of 5-fluorouracil and selumetinib in KRAS or BRAF mutant colon cancer models. Biochemical Pharmacology 160, 110-120.
  • Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP and Parikh SM. (2016). PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature 531, 528-32.
  • Joo MS*, Kim WD*, Lee KY, Kim JH, Koo JH and Kim SG. (2016). AMPK facilitates nuclear accumulation of Nrf2 by phosphorylating at serine 550. Molecular and Cellular Biology 36, 1931-42. (*co-first authors)
Research Topics
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