구성원

구성원

손승우

Seong-Hoon Ahn 안성훈 교수

  • DepartmentDepartmentProf. Dept. of Medicinal and Life Sciences / Professor
  • E-mailE-mailhoon320@hanyang.ac.kr
  • Office PhoneOffice Phone031-400-5518
  • HomepageHomepagehttp://mcblab.net
  • 학과/직책학과/직책과학기술융합대학 의약생명과학과 / 교수
  • 이메일이메일hoon320@hanyang.ac.kr
  • 전화번호전화번호031-400-5518
  • 홈페이지홈페이지http://mcblab.net
Research Keywords
연구키워드
  • #Epigenetics #Transcription regulation #3’-end processing of RNAs #Aging #Lifespan regulation
  • #후성유전학 #유전자 전사 조절 #mRNA 3’-말단 가공 #노화 #수명 조절
Research Objectives
연구목표
  • Regulation of the histone stability and cellular lifespan by the branched-chain amino acids.
  • Lifespan regulation through R-loop formation and mRNA stability.
  • Regulation of cellular lifespan by Spt7 and Sus1, components of the SAGA complex.
  • Regulation of cellular lifespan through the synchronized code of the RNA polymerase II CTD and the histone codes.
  • Interaction between transcription and translation through the ubiquitylation of Rpb1: Its involvement in the regulation of lifespan.
  • 분지아미노산에 의한 히스톤 안정성 및 세포수명 조절.
  • R-loop 형성 및 mRNA 안정성을 통한 세포수명 조절.
  • SAGA 복합체 Spt7 및 Sus1에 의한 세포수명 조절 연구.
  • CTD-히스톤 통합코드에 의한 세포수명 조절.
  • RNA 중합효소의 유비퀴틴화에 의한 전사와 번역의 연계 및 세포 노화와의 상관관계 연구.
Brief Research Experience
주요경력
  • Professor, Hanyang University ERICA Campus (2005-present).
  • Department chair, Dept. of Molecular and Life Science (2009-2011, 2016-2018).
  • Post-Doc, Harvard Medical School (2001~2005).
  • Visiting professor, Harvard Medical School (2018~2019).
  • International cooperation secretary, The Pharmaceutical Society of Korea (2009~2010).
  • Research assistant professor ,Sungkyunkwan University (2005).
  • NRF Mid-career researcher program (2009 ~ 2012, 2012 ~ 2015, 2016 ~ 2021).
  • 교수, 한양대학교 분자생명과학과(2005~현재).
  • 학과장, 분자생명과학과(2009-2011, 2016-2018)
  • 박사후연구원, 하버드 의대(2001~2005).
  • 방문교수, 하버드 의대(2018~2019).
  • 국제협력 간사, 대한약학회(2009~2010).
  • 연구조교수, 성균관대학교(2005).
  • 연구재단 중견연구 과제 수행 (2009 ~ 2012, 2012 ~ 2015, 2016 ~ 2021).
Research Areas
연구분야
  • The development of epigenetic therapeutics against aging and age-related diseases
  • Nuclear mRNA export and Aging
  • CTDK-I and Aging
  • Epigenetic map to aging
  • Epigenetic road to lifespan regulation
  • 후성유전 기반 노화 치료제 개발
  • mRNA 수송과 노화 관련성 연구
  • RNA 중합효소 인산화 효소에 이한 수명조절 연구
  • 후성유전 수명조절 지도 작성
  • 후성유전 수명조절 작용기전 연구
Thesis
논문
  • 1. Lim SJ, Liu Y, Rhie BH, Kim C, Ryu HY, Ahn SH (2022) Sus1 maintains a normal lifespan through regulation of TREX-2 complex-mediated mRNA export. Aging-US., Jun 29: 4990—5012.
  • 2. Park HS, Lee JB, Lee HS, Ahn SH, Ryu HY (2022) Nuclear mRNA Export and Aging. Int J Mol Sci., 13:5451.
  • 3. Lim S, Ahn HJ, Duan R, Liu Y, Ryu HY, Ahn SH (2021) The Spt7 subunit of the SAGA complex is required for the regulation of lifespan in both dividing and nondividing yeast cells. Mech Ageing Dev., 196:111480.
  • 4. Duan R, Ryu HY, Ahn SH. (2020) Symmetric dimethylation on histone H4R3 associates with histone deacetylation to maintain properly polarized cell growth. Res Microbiol., 171:91-98.
  • 5. Srivastava R, Duan R, Ahn SH (2019) Multiple roles of CTDK‑I throughout the cell. Cell Mol Life Sci., 76:2789-2797.
  • 6. Ryu HY, Duan R, Ahn SH (2019) Yeast symmetric arginine methyltransferase Hsl7 has a repressive role in transcription. Res Microbiol., 170:222-229.
  • 7. Srivastava R, Srivastava R, Ahn SH (2016) The Epigenetic Pathways to Ribosomal DNA Silencing. Microbiol Mol Biol Rev., 80:545-63.
  • 8. Srivastava R, Ahn SH (2015) Modifications of RNA polymerase II CTD: Connections to the histone code and cellular function. Biotechnol Adv., 33:856-72.
  • 9. Ryu HY, Ahn SH (2014) Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation. BMC Biol., 12:75.
  • 10. Ryu HY, Rhie BH, Ahn SH (2014) Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells. Biochem Biophys Res Commun., 446:113–118.
Research Topics
연구내용

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