구성원

구성원

임형신

Lee Yong gu 이용구 교수

Research Keywords
연구키워드
  • #CellTreatment #Chimeric Antigen Receptor T cell therapy #Immunology #Cancer Immunotherapy #Cell engineering #Genetic engineering
  • #세포치료제 #키메라 수용체 세포치료제 #면역학 #면역항암치료제 #세포엔지니어링 #유전자재조합
Research Objectives
연구목표
  • Development of the next-generation of Cellular Immunotherapy
  • Development of a novel regulation platform of immune activity
  • 차세대 항암 세포치료제 개발
  • 면역 세포 활성 조절 플랫폼 개발
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Brief Research Experience
주요경력
  • Carrier

    2021.03–present : Assistant Professor, College of Pharmacy, Hanyang University

    2018.08–2021.02 : Post-doctoral fellow, University of PennsylvaniaLout Korea.

  • Research

    9 SCI papers

    1 Patents (5 patents pending)

    1 Licensing-out

  • Funding

    National Research Foundation of Korea

  • 경력

    2021.03–present : 한양대학교 약학대학 조교수

    2018.06–2021.02 : University of Pennsylvania 박사후 연구원

  • 주요연구업적

    SCI 논문 9편

    특허 1건 (출원 5건)

    기술이전 1건

  • 수행과제 지원 기관

    한국연구재단

Research Areas
연구분야
  • Enhancement of anti-tumor activity of cellular immunotherapy
  • Drug delivery via cellular immunotherapy
  • Regulation of immune activation by genetic circuit
  • 유전자 조작을 통한 세포치료제 효능 개선
  • 세포 치료제를 이용한 약물 전달 플랫폼 개발
  • 합성 생물학을 통한 면역 세포 활성 조절
Thesis
논문
  • 1. Lee YG, Guruprasad P, Ghilardi G, et al. (2022) Modulation of BCL-2 in both T cells and tumor cells to enhance chimeric antigen receptor T-cell immunotherapy against cancer. Cancer Discovery, 12(10):2372-2391.
  • 2. Singh N, Lee YG, Shestova O, et al. (2020) Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T-cell DysfunctionDeath Receptor–impaired tumors cause CAR T-cell failure. Cancer Discovery, 10(4):552-567.
  • 3. Lee YG, Marks I, Srinivasarao M, et al. (2019) Use of a single CAR T cell and several bispecific adapters facilitates eradication of multiple antigenically different solid tumors. Cancer Research, 79(2):387-396.
  • 4. Lee YG, Chu H, Lu Y, et al. (2019) Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters. Nature Communications, 10(1):2681
Research Topics
연구내용

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