Identification of triggers of eosinophil extracellular trap
Identification of new functions of lysophosphatidylserine
Regulation of mucin expression in airway epithelial cells
Counterbalance of mucin expression by short chain fatty acids
호산구생물학
호산구세포외덫 유도 염증매개물질 발굴
지질대사체의 신규기능 발굴
기도상피세포에서 점막단백 유전자 발현 조절
짧은사슬지방산에 의한 점막단백유전자 발현 제어
Brief Research Experience
주요경력
Publications of top-rated articles related to eosinophils and allergy in the last 5 years
Basic research funds from NRF for last 25 years
Collaboration with Respiratory and Allergic Department
Collaboration with faculties from the same department
호산구, 알레르기, 점막단백질유전자 발현 조절 등에 관련 상위 25% 논문 다수 출판
한구연구재단으로부터 25년 이상 기초연구 과제 수행 중
호흡기 알레르기 내과 교수와 공동연구 진행 중
학과 교수와 공동 연구 진행 중
Research Areas
연구분야
Identification of eosinophil extracellular DNA trap and its mechanism by lysophosphatidylserine as therapeutic target and biomarker for severe asthma
Formation of eosinophil extracellular trap induced by activated platelets: Identification of pathological role for platelets in allergic inflammation
난치성 천식에서 호산구세포외덫의 역할과 치료표적으로서의 가치 탐색
호산구세포외덫 유도염증물질 동정
짧은사슬지방산에 의한 점막단백발현 제어 기전 연구
Thesis
논문
Sim MS, Kim HJ, Bae I, Kim C, HS Chang, Lee DH, Choi Y, Park HS, Chung IY. (2023) Calcium ionophore-activated platelets induce eosinophil extracellular trap. Allergol Int., Ahead of print
Sim MS, Kim HJ, Jo SH, Kim C, Chung IY. (2022) Lysophosphatidylserine induces MUC5AC production via the feedforward regulation of the TACE-EGFR-ERK pathway in airway epithelial cells in a receptor-independent manner. Int J Mol Sci., 23: 3866
Kim HJ, Sim MS, Lee DH, Kim C, Choi Y, Park HS, Chung IY. (2020) Lysophosphatidylserine induces eosinophil extracellular trap formation and degranulation: Implications in severe asthma. Allergy, 73: 3159-3170
Karam K, Kim HJ, Binas B, Kang JH, Chung IY. (2018) Inflammatory mediators ATP and S100A12 activate the NLRP3 inflammasome to induce MUC5AC production in airway epithelial cells. Biochem Biophys Res Commun., 503: 657-664
Hwang SM, Kim HJ, Kim SM, Jung Y, Park SW, Chung IY. (2018) Lysophosphatidylserine receptor P2Y10: A G-protein coupled receptor that mediates eosinophil degranulation. Clin Exp Allergy, 48: 990-999
DepartmentProf. Dept. of Medicinal and Life Sciences, College of Convergence of Science and Technology / Professor
E-mailiychu@hanyang.ac.kr
Office Phone031-400-5514
Homepagehttps://scholarworks.bwise.kr/erica/researcher-profile?ep=52
