To understand biological problem with bio big data and computation approach.
To understand how molecular feature (DNA, RNA, or protein) is involved with the human disease.
To understand how simple changes (mutation, expression, or regulation) in DNA, RNA, and protein can cause serious disease.
To understand the connection between genetics variation and phenotype.
바이오 빅데이터와 전산접근법으로 생물학적 문제를 이해
분자적 특징(DNA, RNA 또는 단백질)이 인간 질병과 어떻게 관련되어 있는지 이해
DNA, RNA 및 단백질의 단순한 변화(돌연변이, 발현 또는 조절)가 얼마나 심각한 질병을 유발할 수 있는지 이해
유전적 변이와 표현형 사이의 관계
Brief Research Experience
주요경력
Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity. NPJ Precis Oncol. 2022
RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer. Nat Commun. 2018
ASpedia: a comprehensive encyclopedia of human alternative splicing. Nucleic Acids Res. 2018
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet. 2017
poradic Early-onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations but Low Frequency of Somatic RHOA Mutations Compared with Late-onset Cancers. Gastroenterology. 2017
Research Areas
연구분야
Understanding for tumor heterogeneity with single cell resolution.
Finding molecular signatures for liver, pancreas and bile duck
단일세포를 이용한 암의 이질성 이해
간,췌,담도암에 대한 분자 마커 발굴
Thesis
논문
1. Cho SY, Hwang HY, Kim YH, You BC, Han NY, Kong SY, Baek MJ, Kim KH, Lee MR, Park JG, Han SS, Lee WJ, Park C, Park, JB, Kim JY, Park SJ, Woo SM. (2023) Refining classification of cholangiocarcinoma subtypes via proteogenomic integration reveals new therapeutic prospects. Gastroenterology. 9;S0016-5085(23)00237-8.
2. Kim SH, Cho SY. (2023) Single-cell transcriptomics to understand the cellular heterogeneity in toxicology. Mol. Cell. Toxicol. 19, 223–228.
3. Lee K, Hyung D, Cho SY, Yu N, Hong S, Kim J, Kim S, Han JY, Park C. (2023) Splicing signature database development to delineate cancer pathways using literature mining and transcriptome machine learning. Comput Struct Biotechnol J. 2;21:1978-1988.
4. Kim J, Park C, Kim KH, Kim EH, Kim H, Woo JK, Seong JK, Nam KT, Lee YC, Cho SY. (2022) Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity. NPJ Precis Oncol. 27;6(1):9.
5. Hyung D, Baek MJ, Lee J, Cho J, Kim HS, Park C, Cho SY. (2021) Protein-gene expression Nexus: Comprehensive characterization of human cancer cell lines with proteogenomic analysis. Comput Struct Biotechnol J. 17;19:4759-4769.
6. Yang H, Hong D, Cho SY, Park YS, Ko WR, Kim JH, Hur H, Lee J, Kim SJ, Kwon SY, Lee JH, Park DY, Song KS, Chang H, Ryu MH, Cho KS, Kang JW, Kook MC, Thiessen N, He A, Mungall A, Han SU, Kim HK. (2018) RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer. Nat Commun. 25;9(1):4439.
7. Hyung D, Kim J, Cho SY, Park C. (2018) ASpedia: a comprehensive encyclopedia of human alternative splicing. Nucleic Acids Res. 4;46(D1):D58-D63.
8. Cho SY, Park JW, Liu Y, Park YS, Kim JH, Yang H, Um H, Ko WR, Lee BI, Kwon SY, Ryu SW, Kwon CH, Park DY, Lee JH, Lee SI, Song KS, Hur H, Han SU, Chang H, Kim SJ, Kim BS, Yook JH, Yoo MW, Kim BS, Lee IS, Kook MC, Thiessen N, He A, Stewart C, Dunford A, Kim J, Shih J, Saksena G, Cherniack AD, Schumacher S, Weiner AT, Rosenberg M, Getz G, Yang EG, Ryu MH, Bass AJ, Kim HK. (2017) Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers. Gastroenterology. 153(2):536-549
DepartmentProf. Dept. of Medicinal and Life Sciences / Professor
E-mailsooycho@hanyang.ac.kr
Office Phone031-400-5513
Homepagehttps://sites.google.com/view/bcblab
