구성원

구성원

최성경

Jae-yeol Joo 주재열 교수

Research Keywords
연구키워드
  • #RNA #noncoding-RNA #Neurodegenerative diseases #Transcriptome (GWAS) #AI #Cryptic variants #Gene regulation
  • #RNA #비번역RNA #퇴행성뇌질환 #유전체 분석 #인공지능 #숨겨진 유전자 변이 #유전자 발현 조절
Research Objectives
연구목표
  • Therapeutic strategies designed for brain disorder diagnosis from lncRNAs
  • Elucidation of human brain diseases through ncRNA and gene expression
  • Finding novel therapeutic target for human diseases by ultra-long read sequencing
  • Application of an artificial intelligence (AI) in human diseases with GWAS
  • Disease-associated clinical approach through deep learning-based SpliceAI
  • 유전자 발현 및 RNA를 통한 인간의 뇌 질환의 치료와 약물 개발
  • 비번역 RNA를 통한 유전자 발현 조절 매커니즘 해명
  • 전장유전체 분석을 통한 새로운 뇌질환 기전 해명 및 새로운 바이오 마커 발굴
  • 인공지능(AI)와 GWAS를 이용한 인간의 질환관련 숨겨진 변이 발굴
  • Ultra-long read sequencing을 통한 신규 치료 타겟 발굴
Brief Research Experience
주요경력
  • Professor, Hanyang University, Dept. of Pharmacy (2022-present)/li>
  • Principal Investigator, Korea Brain Research Institute (2016-2022)/li>
  • Post-doc fellow, The University of Texas Southwestern Medical Center, Dallas, TX, USA (2012-2016)/li>
  • Nature Neuroscience (IF:28.771, top 0.55%), Journal of infection (IF:38.637, top 2.03%), Molecular Cell (IF:19.328, top 2.2%), Molecular Psychiatry (IF:13.437, top 4.5%), Journal of hematology & oncology (IF:23.618, top 4.5%), PNAS(IF:12.779, top 11.7%), Corresponding author/li>
  • 교수, 한양대학교 약학대학
  • Principal Investigator, 한국뇌연구원
  • 박사후 연구원, The University of Texas Southwestern Medical Center, Dallas, TX, USA
  • Nature Neuroscience (IF:28.771, 상위 0.55%), Journal of infection (IF:38.637, 상위 2.03%), Molecular Cell (IF:19.328, 상위 2.2%), Molecular Psychiatry (IF:13.437, 상위 4.5%), Journal of hematology & oncology (IF:23.618, 상위 4.5%), PNAS(IF:12.779, 상위 11.7%)등 우수저널에 주저자 (교신) 발표
Research Areas
연구분야
  • Elucidation of human brain diseases through RNA and gene expression
  • Therapeutic strategies designed for brain disorder diagnosis from lncRNAs
  • Application of an artificial intelligence (AI) in human diseases with GWAS
  • Finding novel therapeutic target, and cryptic variation for human diseases through ultra-long read sequencing
  • Disease-associated clinical approach through the prediction of alternative splicing variants from human genomic sequence with the deep learning-based SpliceAI
  • RNA 및 유전자 발현을 통한 인간의 뇌 질환 해명
  • 비번역 RNA를 이용한 인간의 다양한 질환에 대한 치료 및 약물 타겟 발굴
  • 인공지능과(AI) 전유전체분석(GWAS)를 이용한 인간의 질환과 관련된 유전자의 변이 발굴
  • Ultra-long read sequencing을 통한 신규 치료 타겟 발굴
  • Splice-AI를 이용한 변이 예측과 임상에서의 적용
Thesis
논문
  • Kim S., Lim K., Yang S., Joo J. (2023) Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease. FASEB Journal., Jan;37(1):e22702. doi: 10.1096/fj.202201197R.
  • Lim, K., Yang S., Kim S., Ko E., Kang M., Joo, J. (2022) Cryptic mutation in phospholipase C of brain disorders: up-to-date discoveries and deep-learning-based approach. Brain., Nov 30;awac451. doi: 10.1093/brain/awac451.
  • Kim S., Yang S., Lim K., Ko E., Jang H., Kang M., Suh P., Joo, J. (2021) Prediction of Alzheimer's disease specific phospholipase c gamma-1 SNV by deep learning based approach for high-throughput screening Proc. Natl. Acad. Sci. U.S.A., Jan 19: 118(3) e2011250118.
  • Kim S., Lim K., Yang S., Joo *. (2021) Long non-coding RNAs in brain tumors: Roles and potential as therapeutic targets. Journal of Hematology & Oncology., May 12; 14(1):77.
  • Yang S., Lim K., Kim S., Joo J. (2021) Molecular landscape of long noncoding RNAs in brain disorders Molecular Psychiatry., Apr;26(4):1060-1074.
  • Lim K., Yang S., Kim S., Joo J. (2020) Elevation of Ace2 as a SARS-CoV-2 entry receptor gene expression in Alzheimer's disease. Journal of Infection., Jun 30:S0163-4453(20)30453-9. doi: 10.1016/j.jinf.2020.06.072.
  • Lim K., Kim S., Yang S., Chun S., Joo J. (2021) Advances in multiplex PCR for Alzheimer's disease diagnostics targeting CDK genes. Neuroscience Letters., Apr 1;749:135715.
  • Lim K., Yang S., Kim S., Joo J. (2021) Identifying new COVID-19 receptor Neuropilin-1 in severe Alzheimer’s diseases patients group brain using genome-wide association study approach. Frontiers in Genetics., Oct 21; 10.3389:741175 (2021).
  • Joo J., Schaukowitch K., Farbiak L., Kilaru G., Kim T. (2016) Stimulus-specific combinatorial functionality of neuronal c-fos enhancers. Nature Neuroscience.,19(1):75-83.
  • Schaukowitch K., Joo J., Liu X., Watts J., Martinez C., Kim T. (2014) Enhancer RNA Facilitates NELF Release from Immediate Early Genes. Molecular Cell., 56(1):29-42.
Research Topics
연구내용