#RNA #비번역RNA #퇴행성뇌질환 #유전체 분석 #인공지능 #숨겨진 유전자 변이 #유전자 발현 조절
Research Objectives
연구목표
Therapeutic strategies designed for brain disorder diagnosis from lncRNAs
Elucidation of human brain diseases through ncRNA and gene expression
Finding novel therapeutic target for human diseases by ultra-long read sequencing
Application of an artificial intelligence (AI) in human diseases with GWAS
Disease-associated clinical approach through deep learning-based SpliceAI
유전자 발현 및 RNA를 통한 인간의 뇌 질환의 치료와 약물 개발
비번역 RNA를 통한 유전자 발현 조절 매커니즘 해명
전장유전체 분석을 통한 새로운 뇌질환 기전 해명 및 새로운 바이오 마커 발굴
인공지능(AI)와 GWAS를 이용한 인간의 질환관련 숨겨진 변이 발굴
Ultra-long read sequencing을 통한 신규 치료 타겟 발굴
Brief Research Experience
주요경력
Professor, Hanyang University, Dept. of Pharmacy (2022-present)/li>
Principal Investigator, Korea Brain Research Institute (2016-2022)/li>
Post-doc fellow, The University of Texas Southwestern Medical Center, Dallas, TX, USA (2012-2016)/li>
Nature Neuroscience (IF:28.771, top 0.55%), Journal of infection (IF:38.637, top 2.03%), Molecular Cell (IF:19.328, top 2.2%), Molecular Psychiatry (IF:13.437, top 4.5%), Journal of hematology & oncology (IF:23.618, top 4.5%), PNAS(IF:12.779, top 11.7%), Corresponding author/li>
교수, 한양대학교 약학대학
Principal Investigator, 한국뇌연구원
박사후 연구원, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Nature Neuroscience (IF:28.771, 상위 0.55%), Journal of infection (IF:38.637, 상위 2.03%), Molecular Cell (IF:19.328, 상위 2.2%), Molecular Psychiatry (IF:13.437, 상위 4.5%), Journal of hematology & oncology (IF:23.618, 상위 4.5%), PNAS(IF:12.779, 상위 11.7%)등 우수저널에 주저자 (교신) 발표
Research Areas
연구분야
Elucidation of human brain diseases through RNA and gene expression
Therapeutic strategies designed for brain disorder diagnosis from lncRNAs
Application of an artificial intelligence (AI) in human diseases with GWAS
Finding novel therapeutic target, and cryptic variation for human diseases through ultra-long read sequencing
Disease-associated clinical approach through the prediction of alternative splicing variants from human genomic sequence with the deep learning-based SpliceAI
RNA 및 유전자 발현을 통한 인간의 뇌 질환 해명
비번역 RNA를 이용한 인간의 다양한 질환에 대한 치료 및 약물 타겟 발굴
인공지능과(AI) 전유전체분석(GWAS)를 이용한 인간의 질환과 관련된 유전자의 변이 발굴
Ultra-long read sequencing을 통한 신규 치료 타겟 발굴
Splice-AI를 이용한 변이 예측과 임상에서의 적용
Thesis
논문
Kim S., Lim K., Yang S., Joo J. (2023) Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease. FASEB Journal., Jan;37(1):e22702. doi: 10.1096/fj.202201197R.
Lim, K., Yang S., Kim S., Ko E., Kang M., Joo, J. (2022) Cryptic mutation in phospholipase C of brain disorders: up-to-date discoveries and deep-learning-based approach. Brain., Nov 30;awac451. doi: 10.1093/brain/awac451.
Kim S., Yang S., Lim K., Ko E., Jang H., Kang M., Suh P., Joo, J. (2021) Prediction of Alzheimer's disease specific phospholipase c gamma-1 SNV by deep learning based approach for high-throughput screening Proc. Natl. Acad. Sci. U.S.A., Jan 19: 118(3) e2011250118.
Kim S., Lim K., Yang S., Joo *. (2021) Long non-coding RNAs in brain tumors: Roles and potential as therapeutic targets. Journal of Hematology & Oncology., May 12; 14(1):77.
Yang S., Lim K., Kim S., Joo J. (2021) Molecular landscape of long noncoding RNAs in brain disorders Molecular Psychiatry., Apr;26(4):1060-1074.
Lim K., Yang S., Kim S., Joo J. (2020) Elevation of Ace2 as a SARS-CoV-2 entry receptor gene expression in Alzheimer's disease. Journal of Infection., Jun 30:S0163-4453(20)30453-9. doi: 10.1016/j.jinf.2020.06.072.
Lim K., Kim S., Yang S., Chun S., Joo J. (2021) Advances in multiplex PCR for Alzheimer's disease diagnostics targeting CDK genes. Neuroscience Letters., Apr 1;749:135715.
Lim K., Yang S., Kim S., Joo J. (2021) Identifying new COVID-19 receptor Neuropilin-1 in severe Alzheimer’s diseases patients group brain using genome-wide association study approach. Frontiers in Genetics., Oct 21; 10.3389:741175 (2021).
Joo J., Schaukowitch K., Farbiak L., Kilaru G., Kim T. (2016) Stimulus-specific combinatorial functionality of neuronal c-fos enhancers. Nature Neuroscience.,19(1):75-83.
Schaukowitch K., Joo J., Liu X., Watts J., Martinez C., Kim T. (2014) Enhancer RNA Facilitates NELF Release from Immediate Early Genes. Molecular Cell., 56(1):29-42.
DepartmentProf. Dept. of Pharmacy, College of Pharmacy / Professor
E-mailjoojy@hanyang.ac.kr
Office Phone031-400-5800
Homepagehttps://molneurobiol.hanyang.ac.kr/
